Medicinal Chemistry
In-depth medicinal chemistry services
At Mithros, we are at the cutting edge of drug discovery chemistry services since 2004, with over two decades of expertise in custom synthesis and medicinal chemistry. Our highly skilled scientists specialize in scaffold design and the synthesis of diverse compound libraries, enabling rapid access to a wide range of molecules for Structure-Activity Relationship (SAR) studies. Combined with our state-of-the-art infrastructure, we consistently deliver molecules with enhanced properties and strong patent potential.
Hit-to-Lead Development
With extensive experience in drug discovery, our scientists efficiently transform initial hits into high-potency leads, facilitating progression into lead optimization. We conduct thorough assessments of hits—considering potency, selectivity, and drug-likeness—to ensure only the most promising candidates advance. Our seasoned team designs analogs with enhanced drug-like properties, reducing the DMTA-cycles and bringing significant value to each program.
Route Scouting and Focused Library Synthesis
Our capabilities in route scouting and focused library synthesis offer a versatile platform to explore and generate novel compounds tailored to client objectives.
Lead Optimization
Following hit-to-lead progression, our scientists focus on optimizing selected leads through a range of in-depth screening and development studies to identify strong preclinical candidates. Our lead optimization services include:
Multi-parameter optimization of lead molecules
In-depth profiling for potency, selectivity, in vitro ADME, in vivo efficacy, and PK/PD characteristics
Efficient process chemistry services to support preclinical efficacy and safety/toxicology studies
Looking for medicinal chemistry services?
Process development
- We are transforming your ideas into products.
- From early discoveries and R&D chemistry in the laboratory to pilot scale for your application testing.
- Always considering economic and safety boundaries and conditions laid out for all stages of the project.
Custom manufacturing
- We are running our own state-of-the-art pilot plant facility with access to a broad supplier network.
- Providing samples of your compounds and specialties in pilot scale for your extended application testing.
- Large-scale synthesis and custom manufacturing opportunities.
Analytical chemistry and purification
- Providing analytical services and quality control for your purpose.
- Several spectroscopic methods available, including NMR, FT-IR, UV/VIS, HPLC etc.